Extremities, sports medicine, digital health and the hospital supply chain remain attractive areas for orthopaedic innovation, according to investors who spoke during this year's Musculoskeletal New Ventures Conference. This seems like a natural course, with extremities and sports medicine being high-growth segments of orthopaedics and innovations in digital health and supply chain routinely mentioned as solutions to complex industry challenges. The sentiment that we took away from the discussion was optimism about the number of investment opportunities available, and about orthopaedics as a whole.

Medartis went public on the SIX Swiss Exchange in March, securing proceeds to fund product development, international expansion and potential acquisitions. Their public launch provided deeper insight into the company's position within the global orthopaedic trauma space. We reviewed Medartis' 2017 and 2018 strategic announcements, and spoke with leadership to get a better sense of the company's recent and future movement.

The forthcoming EU Medical Device Regulation will impact your supply chain, both in manufacturing and distribution. You must talk with your partners now to ensure that you possess the information you need from themand they from youto meet regulatory requirements, your timeline for CE Market Approval and critical considerations for audits. Mike Wolf, Director of Solutions Delivery at Maetrics, outlines some talking points for you and your suppliers.

Zimmer Biomet and Apple have co-developed mymobility, an Apple Watch app designed to facilitate connection between hip and knee replacement patients and their surgical care teams. We believe that the announcement is indicative of forthcoming multi-industry digital health collaborations and products that will seek to shape orthopaedic care primarily in hip and knee recon.

The orthopaedic contract manufacturer market comprises hundreds of companies that serve orthopaedic device manufacturers and, in many cases, other contract manufacturers. We estimate that revenue for this market reached $5 billion in 2017, +7.6% or $360 million from 2016, as published in THE ORTHOPAEDIC INDUSTRY ANNUAL REPORT.

Spine accounts for 18% of the orthopaedic industry's overall revenue. In 2017, sales of spine products (excluding biologics) exceeded $9 billion worldwide, an increase of 2.2% vs. 2016, according to our estimates. The segment remains a story of large, differentiated companies losing market share to the players that derive the majority of their revenue from spine.

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